Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Caspofungin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Caspofungin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, but caspofungin is not an established clinically meaningful inhibitor of this transporter. No clear interaction has been demonstrated with this triple combination.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Caspofungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Caspofungin belongs to Anti Fungals.
Why it happens
Not established; only a theoretical OATP1B1-mediated effect on valsartan hepatic uptake.
What to do
No specific action is needed beyond routine blood pressure monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Caspofungin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Caspofungin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Caspofungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, but caspofungin is not an established clinically meaningful inhibitor of this transporter. No clear interaction has been demonstrated with this triple combination.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Caspofungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine blood pressure monitoring.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
