Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ceritinib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise amlodipine concentrations, causing hypotension and peripheral edema. Ceritinib can also cause bradycardia, which may add to the cardiovascular effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ceritinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and heart rate and reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ceritinib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise amlodipine concentrations, causing hypotension and peripheral edema. Ceritinib can also cause bradycardia, which may add to the cardiovascular effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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