Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Chloroquine
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Chloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine is a weak CYP3A4 inhibitor that could slightly increase amlodipine levels, but the effect is not well documented and is unlikely to be important. Any consequence would be mild additional hypotension.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Chloroquine belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4 metabolism of amlodipine by chloroquine; not firmly established.
What to do
No routine change is needed; monitor blood pressure if the patient reports dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Chloroquine?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine is a weak CYP3A4 inhibitor that could slightly increase amlodipine levels, but the effect is not well documented and is unlikely to be important. Any consequence would be mild additional hypotension.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Chloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure if the patient reports dizziness.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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