Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Entecavir
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidney through filtration and tubular secretion. Drugs that impair renal function, such as thiazides and valsartan in volume-depleted patients, could raise entecavir levels, but the clinical effect is generally small.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Entecavir belongs to Anti Virals.
Why it happens
Possible reduction in renal clearance of entecavir through changes in renal function or competition for tubular secretion.
What to do
Monitor renal function periodically and adjust the entecavir dose according to creatinine clearance if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Entecavir?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidney through filtration and tubular secretion. Drugs that impair renal function, such as thiazides and valsartan in volume-depleted patients, could raise entecavir levels, but the clinical effect is generally small.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and adjust the entecavir dose according to creatinine clearance if renal function declines.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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