Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Erythromycin lactobionate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise amlodipine concentrations, increasing the likelihood of hypotension, flushing and peripheral edema. It may also modestly raise valsartan exposure through inhibition of hepatic OATP1B1 uptake. The effect is usually manageable but can matter in older patients.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4-mediated amlodipine metabolism and may inhibit OATP1B1-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure and for edema or dizziness during and after the erythromycin course, particularly in elderly patients. Reduce the amlodipine dose or choose a non-interacting antibiotic if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise amlodipine concentrations, increasing the likelihood of hypotension, flushing and peripheral edema. It may also modestly raise valsartan exposure through inhibition of hepatic OATP1B1 uptake. The effect is usually manageable but can matter in older patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during and after the erythromycin course, particularly in elderly patients. Reduce the amlodipine dose or choose a non-interacting antibiotic if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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