Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Gemfibrozil
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Gemfibrozil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits OATP1B1, which is involved in the hepatic uptake of valsartan, so valsartan exposure may rise modestly. The clinical significance is thought to be small and the extra blood pressure lowering is generally manageable.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Gemfibrozil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of valsartan by gemfibrozil.
What to do
No dose change is usually needed. Monitor blood pressure when gemfibrozil is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Gemfibrozil?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Gemfibrozil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil inhibits OATP1B1, which is involved in the hepatic uptake of valsartan, so valsartan exposure may rise modestly. The clinical significance is thought to be small and the extra blood pressure lowering is generally manageable.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Gemfibrozil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure when gemfibrozil is started or stopped.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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