Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Glipizide
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce insulin sensitivity, which may weaken the glucose-lowering effect of glipizide. The effect is dose related and often modest at low thiazide doses.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through thiazide-induced hypokalemia, reduced insulin secretion and insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide dose, and keep potassium normal. Adjust antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Glipizide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Glipizide?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce insulin sensitivity, which may weaken the glucose-lowering effect of glipizide. The effect is dose related and often modest at low thiazide doses.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide dose, and keep potassium normal. Adjust antidiabetic therapy if control deteriorates.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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