Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Levoketoconazole
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may increase amlodipine concentrations, causing hypotension and peripheral edema. It may also modestly increase valsartan exposure.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole is a strong CYP3A4 inhibitor, which reduces amlodipine metabolism, and may inhibit OATP1B1-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure and edema, and consider reducing the amlodipine dose while levoketoconazole is taken. Adjust therapy if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Levoketoconazole?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole may increase amlodipine concentrations, causing hypotension and peripheral edema. It may also modestly increase valsartan exposure.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and consider reducing the amlodipine dose while levoketoconazole is taken. Adjust therapy if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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