Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Melatonin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin may raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly reducing amlodipine's effect. The evidence is limited.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Proposed pharmacodynamic antagonism; the mechanism is not firmly established.
What to do
Monitor blood pressure if melatonin is started regularly and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Melatonin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin may raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly reducing amlodipine's effect. The evidence is limited.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if melatonin is started regularly and adjust antihypertensive therapy if control worsens.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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