Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Pretomanid
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid may inhibit OATP1B3, a transporter involved in valsartan hepatic uptake, potentially raising valsartan exposure. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake of valsartan, mainly predicted from in vitro data.
What to do
No dose change is routinely needed. Monitor blood pressure and renal function during the treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Pretomanid?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid may inhibit OATP1B3, a transporter involved in valsartan hepatic uptake, potentially raising valsartan exposure. The clinical significance is uncertain and likely small.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor blood pressure and renal function during the treatment course.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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