Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ruxolitinib
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and could slightly raise ruxolitinib exposure. This is unlikely to be clinically relevant, since only strong inhibitors typically require ruxolitinib dose changes.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated ruxolitinib metabolism by amlodipine.
What to do
No dose adjustment is usually needed. Monitor blood counts as routinely required for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ruxolitinib?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and could slightly raise ruxolitinib exposure. This is unlikely to be clinically relevant, since only strong inhibitors typically require ruxolitinib dose changes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor blood counts as routinely required for ruxolitinib.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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