Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Stiripentol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so amlodipine exposure may rise or fall unpredictably. This may result in hypotension, edema or reduced blood pressure control.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters amlodipine metabolism.
What to do
Monitor blood pressure and edema after starting or changing stiripentol. Adjust amlodipine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Stiripentol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so amlodipine exposure may rise or fall unpredictably. This may result in hypotension, edema or reduced blood pressure control.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema after starting or changing stiripentol. Adjust amlodipine dose according to response.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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