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Drug interactions

Amlodipine-hydrochlorothiazide-valsartan + Temsirolimus

Severity: Moderate

Amlodipine-hydrochlorothiazide-valsartan and Temsirolimus: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

mTOR inhibitors have been associated with angioedema, and the risk appears higher with certain concomitant agents including calcium channel blockers and ARBs. Patients may develop swelling of the face, lips, tongue or airway.

What this interaction means in plain words

Amlodipine-hydrochlorothiazide-valsartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Temsirolimus belongs to Oncology.

Evidence level: Low

Why it happens

Mechanism not fully established; possible additive effects on bradykinin-mediated pathways and vascular permeability.

What to do

Counsel the patient to report facial or lip swelling promptly. Stop the offending drugs and treat if angioedema occurs.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Amlodipine-hydrochlorothiazide-valsartan with Temsirolimus?

MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors have been associated with angioedema, and the risk appears higher with certain concomitant agents including calcium channel blockers and ARBs. Patients may develop swelling of the face, lips, tongue or airway.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Temsirolimus?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report facial or lip swelling promptly. Stop the offending drugs and treat if angioedema occurs.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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