Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Vadadustat
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is an OAT3 substrate, and inhibition of OAT transporters may increase its exposure. Valsartan's inhibitory effect on this pathway is likely small, but a larger than intended hemoglobin rise is possible.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3-mediated renal transport of vadadustat.
What to do
Monitor hemoglobin and adjust the vadadustat dose per labeling if it rises too rapidly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Vadadustat?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat is an OAT3 substrate, and inhibition of OAT transporters may increase its exposure. Valsartan's inhibitory effect on this pathway is likely small, but a larger than intended hemoglobin rise is possible.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the vadadustat dose per labeling if it rises too rapidly.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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