Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Avapritinib
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Avapritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and amlodipine is a weak CYP3A4 inhibitor, so a small increase in avapritinib exposure is possible. This is unlikely to matter clinically, though avapritinib has dose-related cognitive and bleeding effects.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Avapritinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine may modestly reduce avapritinib clearance.
What to do
No empirical dose change is needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Avapritinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Avapritinib?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is a CYP3A4 substrate, and amlodipine is a weak CYP3A4 inhibitor, so a small increase in avapritinib exposure is possible. This is unlikely to matter clinically, though avapritinib has dose-related cognitive and bleeding effects.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Avapritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
