Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Carbamazepine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and hydrochlorothiazide can cause hyponatremia, and together the risk is increased. Severe hyponatremia may cause confusion, seizures and falls. Carbamazepine, as a CYP3A4 inducer, may also lower amlodipine levels.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Additive effects on sodium balance, with thiazide-induced renal sodium loss and carbamazepine-related ADH effects, plus CYP3A4 induction affecting amlodipine.
What to do
Check serum sodium at baseline and periodically, especially in older patients and after dose changes. Consider a different antihypertensive if hyponatremia develops, and monitor blood pressure for reduced amlodipine effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Carbamazepine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and hydrochlorothiazide can cause hyponatremia, and together the risk is increased. Severe hyponatremia may cause confusion, seizures and falls. Carbamazepine, as a CYP3A4 inducer, may also lower amlodipine levels.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially in older patients and after dose changes. Consider a different antihypertensive if hyponatremia develops, and monitor blood pressure for reduced amlodipine effect.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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