Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Clarithromycin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and can raise amlodipine exposure. This may cause excessive vasodilation with hypotension, peripheral edema and, in some cases, acute kidney injury, particularly in older patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4-mediated metabolism of amlodipine, increasing its plasma concentrations.
What to do
Monitor blood pressure and renal function during the clarithromycin course and for several days after, especially in the elderly. Consider an alternative macrolide such as azithromycin if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Clarithromycin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and can raise amlodipine exposure. This may cause excessive vasodilation with hypotension, peripheral edema and, in some cases, acute kidney injury, particularly in older patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during the clarithromycin course and for several days after, especially in the elderly. Consider an alternative macrolide such as azithromycin if feasible.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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