Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Crizotinib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations. This can increase hypotension and edema. Crizotinib itself can cause bradycardia, so additive effects on heart rate and blood pressure are possible.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and heart rate, and watch for peripheral edema. Reduce the amlodipine dose or switch to an alternative antihypertensive if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations. This can increase hypotension and edema. Crizotinib itself can cause bradycardia, so additive effects on heart rate and blood pressure are possible.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and watch for peripheral edema. Reduce the amlodipine dose or switch to an alternative antihypertensive if hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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