Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Dalteparin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone secretion and may cause hyperkalemia. Combined with an angiotensin receptor blocker such as olmesartan, the risk of elevated potassium is increased, especially in renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to the potassium-retaining effect of angiotensin receptor blockade.
What to do
Check serum potassium and renal function if treatment lasts more than a few days or in patients at risk. The thiazide component may partly offset the effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dalteparin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone secretion and may cause hyperkalemia. Combined with an angiotensin receptor blocker such as olmesartan, the risk of elevated potassium is increased, especially in renal impairment or diabetes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function if treatment lasts more than a few days or in patients at risk. The thiazide component may partly offset the effect.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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