Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Eslicarbazepine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and may lower amlodipine concentrations. The effect is likely modest. Eslicarbazepine can also cause hyponatremia, which may be compounded by the thiazide.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases amlodipine metabolism, and eslicarbazepine plus thiazide have additive sodium-lowering effects.
What to do
Monitor blood pressure and serum sodium after starting or changing eslicarbazepine. Adjust antihypertensive dosing if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Eslicarbazepine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak CYP3A4 inducer and may lower amlodipine concentrations. The effect is likely modest. Eslicarbazepine can also cause hyponatremia, which may be compounded by the thiazide.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum sodium after starting or changing eslicarbazepine. Adjust antihypertensive dosing if control is lost.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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