Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Esmolol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and the three antihypertensive components have additive blood pressure lowering effects, with a risk of hypotension and bradycardia. Beta-blockade may also increase potassium slightly and mask hypoglycemia signs.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of beta-1 blockade with calcium channel blockade, ARB and diuretic.
What to do
Monitor blood pressure and heart rate continuously during esmolol infusion and adjust the infusion rate accordingly. Hold or reduce the oral antihypertensives if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Esmolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and the three antihypertensive components have additive blood pressure lowering effects, with a risk of hypotension and bradycardia. Beta-blockade may also increase potassium slightly and mask hypoglycemia signs.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during esmolol infusion and adjust the infusion rate accordingly. Hold or reduce the oral antihypertensives if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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