Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ethacrynic acid
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, can cause marked volume depletion, hypokalemia, hyponatremia and hypotension. Olmesartan adds to the hypotensive and renal risk through reduced glomerular filtration pressure.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive diuretic-induced electrolyte loss and volume depletion, combined with ARB-related reduction in glomerular filtration pressure.
What to do
Monitor serum electrolytes, renal function and blood pressure, and reduce diuretic doses if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, can cause marked volume depletion, hypokalemia, hyponatremia and hypotension. Olmesartan adds to the hypotensive and renal risk through reduced glomerular filtration pressure.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum electrolytes, renal function and blood pressure, and reduce diuretic doses if volume depletion occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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