Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Flibanserin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may raise flibanserin concentrations. Higher exposure increases the risk of hypotension, syncope and sedation, especially when several weak inhibitors are used together or alcohol is consumed.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4 by amlodipine reduces the metabolism of flibanserin.
What to do
Monitor for dizziness, hypotension and sedation, particularly if more than one weak CYP3A4 inhibitor is taken. Advise the patient to avoid alcohol and to take flibanserin at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Flibanserin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may raise flibanserin concentrations. Higher exposure increases the risk of hypotension, syncope and sedation, especially when several weak inhibitors are used together or alcohol is consumed.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation, particularly if more than one weak CYP3A4 inhibitor is taken. Advise the patient to avoid alcohol and to take flibanserin at bedtime.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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