Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Fluconazole
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and can raise amlodipine concentrations. This may cause excessive vasodilation, with hypotension, dizziness and peripheral oedema.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4-mediated metabolism of amlodipine, increasing its exposure.
What to do
Monitor blood pressure and for oedema during fluconazole therapy. Consider reducing the amlodipine dose if hypotension or symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Fluconazole?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and can raise amlodipine concentrations. This may cause excessive vasodilation, with hypotension, dizziness and peripheral oedema.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for oedema during fluconazole therapy. Consider reducing the amlodipine dose if hypotension or symptoms develop.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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