Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Furosemide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding furosemide to a thiazide-containing combination produces sequential nephron blockade, causing marked diuresis, volume depletion, hypotension and electrolyte disturbances such as hypokalemia and hyponatremia. The olmesartan component may counter potassium loss, but renal function can worsen with volume depletion.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Loop and thiazide diuretics act at different nephron sites with additive natriuresis and potassium wasting, while ARB-induced reduction of glomerular pressure adds to the renal risk.
What to do
Monitor electrolytes, renal function, weight and blood pressure after starting or changing the dose. Adjust diuretic doses if volume depletion or electrolyte abnormalities occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Furosemide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding furosemide to a thiazide-containing combination produces sequential nephron blockade, causing marked diuresis, volume depletion, hypotension and electrolyte disturbances such as hypokalemia and hyponatremia. The olmesartan component may counter potassium loss, but renal function can worsen with volume depletion.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure after starting or changing the dose. Adjust diuretic doses if volume depletion or electrolyte abnormalities occur.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
