Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Gentamicin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide-induced volume depletion and electrolyte loss, plus ARB effects on glomerular filtration, can increase the nephrotoxic risk of gentamicin. Hypokalemia and hypomagnesemia from the diuretic may also add to aminoglycoside-related toxicity.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Volume depletion and reduced renal perfusion from the diuretic and ARB increase aminoglycoside accumulation and nephrotoxicity, with additive electrolyte wasting.
What to do
Monitor serum creatinine, gentamicin levels, potassium and magnesium, and keep the patient hydrated. Consider temporarily holding the diuretic and ARB during acute illness or when renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Gentamicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide-induced volume depletion and electrolyte loss, plus ARB effects on glomerular filtration, can increase the nephrotoxic risk of gentamicin. Hypokalemia and hypomagnesemia from the diuretic may also add to aminoglycoside-related toxicity.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, gentamicin levels, potassium and magnesium, and keep the patient hydrated. Consider temporarily holding the diuretic and ARB during acute illness or when renal function declines.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
