Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Insulin glargine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide in the combination may work in the opposite direction by raising glucose.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
ARBs may improve insulin sensitivity, while thiazides can impair glucose tolerance; the net mechanism is not fully established.
What to do
Increase blood glucose monitoring when the combination is started or changed. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Insulin glargine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide in the combination may work in the opposite direction by raising glucose.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring when the combination is started or changed. Adjust the insulin dose as needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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