Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Labetalol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding labetalol to a triple antihypertensive combination produces additive blood pressure lowering, with a risk of symptomatic hypotension, dizziness and falls, particularly at initiation or dose increases. Beta-blockade can also blunt the reflex tachycardia that normally offsets vasodilation from amlodipine.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha/beta-adrenergic blockade combined with calcium channel blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate, including standing readings, when starting or adjusting either regimen, and reduce doses if hypotension occurs. Check potassium and renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding labetalol to a triple antihypertensive combination produces additive blood pressure lowering, with a risk of symptomatic hypotension, dizziness and falls, particularly at initiation or dose increases. Beta-blockade can also blunt the reflex tachycardia that normally offsets vasodilation from amlodipine.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including standing readings, when starting or adjusting either regimen, and reduce doses if hypotension occurs. Check potassium and renal function periodically.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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