Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Letermovir
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits hepatic uptake transporters and can increase olmesartan exposure. This may enhance blood pressure lowering and other olmesartan adverse effects.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits OATP1B1/3, reducing hepatic uptake of olmesartan.
What to do
Monitor blood pressure, renal function and potassium during coadministration. Reduce the olmesartan dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Letermovir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits hepatic uptake transporters and can increase olmesartan exposure. This may enhance blood pressure lowering and other olmesartan adverse effects.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during coadministration. Reduce the olmesartan dose if hypotension or adverse effects occur.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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