Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Lonafarnib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and CYP3A inhibitor, while amlodipine is a weak CYP3A inhibitor and substrate. Exposure of both may rise, increasing lonafarnib toxicity and amlodipine-related hypotension and edema.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Mutual competition for and inhibition of CYP3A4 metabolism.
What to do
Keep lonafarnib at its starting dose and monitor for palpitations, syncope and ECG changes. Monitor blood pressure and reduce amlodipine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lonafarnib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and CYP3A inhibitor, while amlodipine is a weak CYP3A inhibitor and substrate. Exposure of both may rise, increasing lonafarnib toxicity and amlodipine-related hypotension and edema.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep lonafarnib at its starting dose and monitor for palpitations, syncope and ECG changes. Monitor blood pressure and reduce amlodipine if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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