Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Lurasidone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effects of the three antihypertensive components. Dizziness, syncope and falls are the main concerns, especially early in treatment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotension from antipsychotic alpha-1 adrenergic antagonism combined with antihypertensive mechanisms.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing lurasidone, and lower the antihypertensive doses if needed. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lurasidone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effects of the three antihypertensive components. Dizziness, syncope and falls are the main concerns, especially early in treatment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing lurasidone, and lower the antihypertensive doses if needed. Advise patients to rise slowly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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