Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Magnesium oxide
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss, which can reduce serum magnesium over time. Oral magnesium oxide supplementation may partly offset this loss, so the combination is generally not harmful.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide diuretics increase renal excretion of magnesium, opposing the effect of magnesium supplementation.
What to do
Monitor serum magnesium periodically during long-term thiazide therapy and adjust the magnesium dose if hypomagnesemia persists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Magnesium oxide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss, which can reduce serum magnesium over time. Oral magnesium oxide supplementation may partly offset this loss, so the combination is generally not harmful.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium periodically during long-term thiazide therapy and adjust the magnesium dose if hypomagnesemia persists.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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