Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Mefenamic acid
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Mefenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can reduce the blood pressure lowering effect of the combination and, together with olmesartan and hydrochlorothiazide, increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID-mediated inhibition of vasodilatory renal prostaglandins reduces renal perfusion and causes sodium retention, opposing antihypertensive and diuretic actions.
What to do
Avoid prolonged NSAID use, or use the lowest dose for a short course with adequate hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Mefenamic acid?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mefenamic acid can reduce the blood pressure lowering effect of the combination and, together with olmesartan and hydrochlorothiazide, increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use, or use the lowest dose for a short course with adequate hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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