Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Mefloquine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia, conduction abnormalities and QT effects, and amlodipine may add to hypotension or conduction effects. Pharmacokinetic increases in amlodipine levels are not well established, so the clinical significance is uncertain. Hydrochlorothiazide-induced hypokalemia or hypomagnesemia could also add to arrhythmia risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Mainly additive pharmacodynamic cardiac and hypotensive effects, with a possible minor metabolic interaction not firmly established.
What to do
Check electrolytes, particularly potassium and magnesium, and correct deficits before and during mefloquine therapy. Monitor heart rate and blood pressure, and consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause bradycardia, conduction abnormalities and QT effects, and amlodipine may add to hypotension or conduction effects. Pharmacokinetic increases in amlodipine levels are not well established, so the clinical significance is uncertain. Hydrochlorothiazide-induced hypokalemia or hypomagnesemia could also add to arrhythmia risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes, particularly potassium and magnesium, and correct deficits before and during mefloquine therapy. Monitor heart rate and blood pressure, and consider an ECG in patients with cardiac risk factors.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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