Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Memantine
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is partly eliminated by renal tubular secretion, and hydrochlorothiazide may reduce its clearance. Hydrochlorothiazide may also reduce memantine exposure. The effect is unlikely to be clinically important in most patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible interaction at renal tubular secretion pathways; not well characterized.
What to do
No routine adjustment is needed; watch for dizziness or confusion in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Memantine?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is partly eliminated by renal tubular secretion, and hydrochlorothiazide may reduce its clearance. Hydrochlorothiazide may also reduce memantine exposure. The effect is unlikely to be clinically important in most patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for dizziness or confusion in patients with renal impairment.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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