Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ribociclib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations, raising the likelihood of hypotension and edema. Hydrochlorothiazide-induced electrolyte disturbances also matter because ribociclib prolongs the QT interval.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing amlodipine clearance; thiazide hypokalemia adds to ribociclib QT risk.
What to do
Monitor blood pressure and edema and reduce the amlodipine dose if needed. Check potassium and magnesium and correct them before and during ribociclib therapy, with ECG monitoring as per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ribociclib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations, raising the likelihood of hypotension and edema. Hydrochlorothiazide-induced electrolyte disturbances also matter because ribociclib prolongs the QT interval.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the amlodipine dose if needed. Check potassium and magnesium and correct them before and during ribociclib therapy, with ECG monitoring as per labeling.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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