Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Simvastatin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine raises simvastatin exposure, which increases the risk of myopathy and rhabdomyolysis. Labeling restricts the simvastatin dose when the two are used together.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4-mediated metabolism of simvastatin, which raises simvastatin and active metabolite concentrations.
What to do
Limit simvastatin to 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Simvastatin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine raises simvastatin exposure, which increases the risk of myopathy and rhabdomyolysis. Labeling restricts the simvastatin dose when the two are used together.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit simvastatin to 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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