Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Succinylcholine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine causes a rise in serum potassium, whereas thiazide therapy can cause hypokalemia and alter neuromuscular blockade. Electrolyte shifts during anesthesia may increase arrhythmia risk, and olmesartan adds hyperkalemia potential.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Depolarizing blockade releases potassium from muscle, while thiazide-induced potassium and magnesium depletion and ARB-related potassium retention alter the net potassium balance.
What to do
Check serum potassium before elective surgery and correct abnormalities. Monitor ECG and potassium perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Succinylcholine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine causes a rise in serum potassium, whereas thiazide therapy can cause hypokalemia and alter neuromuscular blockade. Electrolyte shifts during anesthesia may increase arrhythmia risk, and olmesartan adds hyperkalemia potential.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before elective surgery and correct abnormalities. Monitor ECG and potassium perioperatively.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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