Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Tacrolimus
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine may modestly increase tacrolimus blood concentrations in some patients, probably through CYP3A4 competition. Higher tacrolimus levels raise the risk of nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Amlodipine may weakly inhibit CYP3A4-mediated tacrolimus metabolism; the mechanism is not firmly established.
What to do
Monitor tacrolimus trough levels and renal function after starting or changing amlodipine, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine may modestly increase tacrolimus blood concentrations in some patients, probably through CYP3A4 competition. Higher tacrolimus levels raise the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function after starting or changing amlodipine, and adjust the tacrolimus dose accordingly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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