Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Torsemide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide, a loop diuretic, adds to the diuretic and potassium-wasting effect of hydrochlorothiazide, while olmesartan tends to raise potassium. Combined use may cause hypotension, volume depletion, electrolyte disturbances and renal impairment, especially at treatment initiation.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Additive diuretic and blood pressure lowering effects, with opposing effects on potassium from loop/thiazide diuretics and angiotensin receptor blockade.
What to do
Monitor blood pressure, serum potassium, magnesium, sodium and creatinine after starting or changing doses. Reduce diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Torsemide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Torsemide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide, a loop diuretic, adds to the diuretic and potassium-wasting effect of hydrochlorothiazide, while olmesartan tends to raise potassium. Combined use may cause hypotension, volume depletion, electrolyte disturbances and renal impairment, especially at treatment initiation.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, magnesium, sodium and creatinine after starting or changing doses. Reduce diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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