Drug interactions
Amlodipine-perindopril + Axitinib
Severity: Minor
Amlodipine-perindopril and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may slightly raise axitinib exposure. Axitinib itself can cause hypertension, so blood pressure control is also relevant. The clinical effect of the interaction is probably small.
What this interaction means in plain words
Amlodipine-perindopril and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated axitinib metabolism by amlodipine.
What to do
Monitor for axitinib adverse effects such as hypertension and diarrhea, and adjust antihypertensives as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-perindopril with Axitinib?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and may slightly raise axitinib exposure. Axitinib itself can cause hypertension, so blood pressure control is also relevant. The clinical effect of the interaction is probably small.
How serious is the interaction between Amlodipine-perindopril and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for axitinib adverse effects such as hypertension and diarrhea, and adjust antihypertensives as needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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