Drug interactions
Amlodipine-perindopril + Brimonidine
Severity: Minor
Amlodipine-perindopril and Brimonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can lower blood pressure when absorbed systemically, and may add to the effects of perindopril. With ophthalmic use the effect is usually small but hypotension can occur in susceptible patients.
What this interaction means in plain words
Amlodipine-perindopril and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Brimonidine belongs to Miscellaneous.
Why it happens
Additive hypotensive effect from central alpha-2 agonism and ACE inhibition.
What to do
Monitor blood pressure if symptoms of dizziness or hypotension occur, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Brimonidine?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can lower blood pressure when absorbed systemically, and may add to the effects of perindopril. With ophthalmic use the effect is usually small but hypotension can occur in susceptible patients.
How serious is the interaction between Amlodipine-perindopril and Brimonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if symptoms of dizziness or hypotension occur, especially in older patients.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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