Drug interactions
Amlodipine-perindopril + Drospirenone
Severity: Moderate
Amlodipine-perindopril and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can increase serum potassium, and ACE inhibitors add to this effect. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Amlodipine-perindopril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive reduction in aldosterone-mediated potassium excretion through ACE inhibition and mineralocorticoid receptor antagonism.
What to do
Check serum potassium during the first cycle of combined use and periodically thereafter, particularly in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Amlodipine-perindopril with Drospirenone?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can increase serum potassium, and ACE inhibitors add to this effect. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs.
How serious is the interaction between Amlodipine-perindopril and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically thereafter, particularly in patients with renal impairment.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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