Drug interactions
Amlodipine-perindopril + Enoxaparin
Severity: Moderate
Amlodipine-perindopril and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. With an ACE inhibitor this may cause clinically important hyperkalemia, especially in renal impairment, diabetes or with prolonged use.
What this interaction means in plain words
Amlodipine-perindopril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to ACE inhibitor-related reduction in potassium excretion.
What to do
Monitor serum potassium and renal function in patients on prolonged or high-risk enoxaparin therapy with perindopril.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Enoxaparin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. With an ACE inhibitor this may cause clinically important hyperkalemia, especially in renal impairment, diabetes or with prolonged use.
How serious is the interaction between Amlodipine-perindopril and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function in patients on prolonged or high-risk enoxaparin therapy with perindopril.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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