Drug interactions
Amlodipine-perindopril + Istradefylline
Severity: Minor
Amlodipine-perindopril and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which may increase amlodipine concentrations. This effect was not seen at 20 mg daily. Hypotension and edema are possible.
What this interaction means in plain words
Amlodipine-perindopril and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema if istradefylline 40 mg daily is used, and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Amlodipine-perindopril with Istradefylline?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which may increase amlodipine concentrations. This effect was not seen at 20 mg daily. Hypotension and edema are possible.
How serious is the interaction between Amlodipine-perindopril and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema if istradefylline 40 mg daily is used, and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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