Drug interactions
Amlodipine-perindopril + Ketoconazole
Severity: Moderate
Amlodipine-perindopril and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure. This may cause excessive vasodilation with hypotension, peripheral edema and reflex tachycardia.
What this interaction means in plain words
Amlodipine-perindopril and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism increases plasma amlodipine concentrations.
What to do
Monitor blood pressure and edema when ketoconazole is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Ketoconazole?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure. This may cause excessive vasodilation with hypotension, peripheral edema and reflex tachycardia.
How serious is the interaction between Amlodipine-perindopril and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when ketoconazole is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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