Drug interactions
Amlodipine-perindopril + Larotrectinib
Severity: Minor
Amlodipine-perindopril and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is metabolized by CYP3A4 and has been reported as a weak CYP3A4 inhibitor, so an increase in amlodipine exposure is possible but it is predicted to be small. Clinical significance is uncertain.
What this interaction means in plain words
Amlodipine-perindopril and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated amlodipine metabolism by larotrectinib.
What to do
No dose adjustment is expected; monitor blood pressure and peripheral edema when starting larotrectinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Amlodipine-perindopril with Larotrectinib?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is metabolized by CYP3A4 and has been reported as a weak CYP3A4 inhibitor, so an increase in amlodipine exposure is possible but it is predicted to be small. Clinical significance is uncertain.
How serious is the interaction between Amlodipine-perindopril and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected; monitor blood pressure and peripheral edema when starting larotrectinib.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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