Drug interactions
Amlodipine-perindopril + Nifedipine
Severity: Moderate
Amlodipine-perindopril and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amlodipine and nifedipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds vasodilatory effects, with risk of hypotension, edema and reflex tachycardia, with no real benefit.
What this interaction means in plain words
Amlodipine-perindopril and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive calcium channel blockade; nifedipine is a CYP3A4 substrate with only a minor pharmacokinetic effect on amlodipine.
What to do
Avoid using two dihydropyridines together and keep a single agent. If both are given, monitor blood pressure and peripheral edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Amlodipine-perindopril with Nifedipine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amlodipine and nifedipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds vasodilatory effects, with risk of hypotension, edema and reflex tachycardia, with no real benefit.
How serious is the interaction between Amlodipine-perindopril and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridines together and keep a single agent. If both are given, monitor blood pressure and peripheral edema.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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