Drug interactions
Amlodipine-perindopril + Rocuronium
Severity: Minor
Amlodipine-perindopril and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may enhance the effect of non-depolarizing neuromuscular blockers. Blockade could be deeper or last longer than anticipated during surgery.
What this interaction means in plain words
Amlodipine-perindopril and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may impair neuromuscular transmission, adding to nondepolarizing blockade.
What to do
Use neuromuscular monitoring and titrate rocuronium to effect, with reversal agent available.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Rocuronium
Frequently asked questions
Can I take Amlodipine-perindopril with Rocuronium?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may enhance the effect of non-depolarizing neuromuscular blockers. Blockade could be deeper or last longer than anticipated during surgery.
How serious is the interaction between Amlodipine-perindopril and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use neuromuscular monitoring and titrate rocuronium to effect, with reversal agent available.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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