Drug interactions
Amlodipine-perindopril + Tadalafil
Severity: Moderate
Amlodipine-perindopril and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator through PDE5 inhibition and can add to the blood pressure lowering of amlodipine and perindopril. This may cause symptomatic hypotension, particularly in older or volume-depleted patients.
What this interaction means in plain words
Amlodipine-perindopril and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation via PDE5 inhibition, calcium channel blockade and ACE inhibition.
What to do
Use the lowest tadalafil dose initially and counsel the patient about dizziness. Monitor blood pressure after starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Tadalafil?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator through PDE5 inhibition and can add to the blood pressure lowering of amlodipine and perindopril. This may cause symptomatic hypotension, particularly in older or volume-depleted patients.
How serious is the interaction between Amlodipine-perindopril and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest tadalafil dose initially and counsel the patient about dizziness. Monitor blood pressure after starting.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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